Although droplet infection is most frequent, contact infection is also an important infection route 1, 4 6. I virus a e c infettano diverse specie, mentre il virus b infetta quasi esclusivamente luomo. Some cases among the ongoing influenzalike illness outbreaks in the united states may be not caused by influenza virus but by a human adenovirus type 4 variant usually found in military settings. Prevention of influenza a virus iav transmission during annual outbreaks of seasonal influenza is a major issue 1 3. Influenza a virus causes influenza in birds and some mammals, and is the only species of the genus alphainfluenzavirus of the virus family orthomyxoviridae. The journal welcomes submitted articles on virus replication, virushost biology, viral pathogenesis.
Influenza diagnosis clinical and epidemiological characteristics increase of febrile respiratory illness lab isolation of influenza virus from clinical specimen e. Antiviral therapy and outcomes of patients with pneumonia. Influenza a virus was transmitted in a laboratory setting when a researcher was infected by a ferret that had been infected with a strain of influenza a virus and which sneezed violently at close range while it was being examined. Influenza a viruses can be broken down into subtypes depending on the genes that make up the surface proteins. Influenza a virus an overview sciencedirect topics. West nile virus wnv, a neurotropic flavivirus, is the leading cause of viral encephalitis in the united states. In our recent report, influenza a ph1n1 virus rna was still detectable in autopsy lung tissue from a 44yearold previously healthy man 25 days after illness onset. Drifting, or antigenic drift, is a gradual, continuous change that occurs when the virus makes small mistakes when copying its genetic information. Influenza virus is one of the most changeable viruses known.
We have been publishing the results of basic research in all branches of virology for over 60 years. This new h1n1 virus contained a unique combination of influenza genes not previously identified in animals or people. I nostri contenuti sono scritti per essere alla portata di tutti. This work is licensed under a creative commons attribution.
Local pigs were the source of this human infection. Influenza viruses are often identified by their h and n spikes. At the tips of these spikes are structures that allow the virus to attach and enter a cell, like the influenza virus hemagglutinin spikes h or enzymes like the neuraminidase n influenza virus spikes that allow the virus to detach from the cell surface during release of new virions. It was detected first in the united states and spread quickly across the united states and the world. A, b, c, and only types a and b are perceived to be clinically relevant in humans. Influenzavirus a, influenzavirus b, influenzavirus c. The influenza viruses section of virology journal will publish articles on all aspects of influenza virus research, including molecular genetics, molecular biology, biochemistry, biophysics, structural biology, cell biology, immunology, morphology, and pathogenesis. Because swine influenza virus infection is seldom diagnosed in humans, its frequency might be underestimated. Hand hygiene is a commonly used method for prevention of contact infection and is recommended by the. Wildtype yellow fever virus rna in cerebrospinal fluid of. Este proceso difiere entre diversos virus dependiendo del material genetico. The section will also welcome the case reports of influenza outbreaks in both. Type a influenza is a contagious viral infection that can have lifethreatening complications if left untreated.
Other species including horses and dogs also hav e their own varieties of influenza viruses. Influenza a virus, influenza b virus, and influenza c virus, respectively table 10. We report a immunocompromised hematologic patient with swine influenza ah3n2 virus in 2014 in italy. The latter are composed of key genes from the 1918 virus, updated by subsequentlyincorporated avian influenza genes that code for novel surface proteins, making the 1918 virus indeed the mother of all pandemics. Influenza a symptoms can be confused with signs of other conditions but are usually. Countries able to perform pcr to diagnose influenza a h1n1 virus infection in humans 7 may 2009 revision 4 first published on 2 may 2009 based on performance in the who external quality assessment project eqap1, national influenza centres nics of the who global influenza surveillance. How the flu virus can change influenza viruses can change in two different waysantigenic drift and antigenic shift.
But few data are available for influenza virus detection in the context of surveillance systems. Influenza, gripe, virus respiratorios, infecciones respiratorias agudas. We have found that the most reliable method for influenza virus detection is svpcr. Chapitre 7 grippe infection par le virus influenza. Virus microbiologia y parasitologia virus vih sida. There are two ways that influenza virus changes these are called drift and shift. Virology publishes papers that provide advances to the understanding of virus biology. Transmission of influenza viruses from animals to people influenza a viruses also are found in many different animals, including ducks, chickens, pigs, whales, horses and seals. The influenza a and b viruses that routinely spread in people human influenza viruses are responsible for seasonal flu epidemics each year. Humans can also be infected with influenza viruses that are routinely circulating in animal s, such as avian influenza virus subtypes ah5n1 and ah9n2 and swine influenza virus subtypes ah1n1 and h3n2. Influenza a virus definition of influenza a virus by the. In a typical year, 1020% of the population in the united states are infected by influenza virus, resulting in up to 40,000.
The mixovirus influenzae is the agent that causes influenza, commonly called flu. To assess the relevance of these findings for human disease, we performed virological and immunological studies in 18 individuals with h5n1 and 8 individuals infected with human influenza virus. Zdna binding protein 1 zbp1 is a cytoplasmic sensor that that has been shown to play a. Some isolates of influenza a virus cause severe disease both in domestic poultry and, rarely, in humans. Countries able to perform pcr to diagnose influenza a. Due to the segmented nature of its genetic material, the influenza virus is highly mutagenic. We detected wildtype yellow fever virus rna by reverse transcription pcr in the csf of a previously healthy child who died during a yellow fever outbreak in brazil. Testing of diagnostic methods for detection of influenza. Strains of all subtypes of influenza a virus have been isolated from wild birds, although disease is uncommon. Three genera exist with this family that pertain to influenza viruses, influenzavirus a, influenzavirus b, and influenzavirus c, each of which contain a single species, or type. Zdnabinding protein 1 is critical for controlling virus.